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Vasculopathy and pulmonary hypertension in sickle cell disease
Sickle cell disease (SCD) is an autosomal recessive disorder in the gene encoding the β-chain of hemoglobin. Deoxygenation causes the mutant hemoglobin S to polymerize, resulting in rigid, adherent red blood cells that are entrapped in the microcirculation and hemolyze. Cardinal features include sev...
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| Veröffentlicht in: | Am J Physiol Lung Cell Mol Physiol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4329471/ https://ncbi.nlm.nih.gov/pubmed/25398989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00252.2014 |
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