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Vasculopathy and pulmonary hypertension in sickle cell disease

Sickle cell disease (SCD) is an autosomal recessive disorder in the gene encoding the β-chain of hemoglobin. Deoxygenation causes the mutant hemoglobin S to polymerize, resulting in rigid, adherent red blood cells that are entrapped in the microcirculation and hemolyze. Cardinal features include sev...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Potoka, Karin P., Gladwin, Mark T.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329471/
https://ncbi.nlm.nih.gov/pubmed/25398989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00252.2014
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