Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice

Pulmonary hypertension (PH) is a leading cause of death in sickle cell disease (SCD) patients. Hemolysis and oxidative stress contribute to SCD-associated PH. We have reported that the protein thrombospondin-1 (TSP1) is elevated in the plasma of patients with SCD and, by interacting with its recepto...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Novelli, Enrico M., Little-Ihrig, Lynda, Knupp, Heather E., Rogers, Natasha M., Yao, Mingyi, Baust, Jeffrey J., Meijles, Daniel, St. Croix, Claudette M., Ross, Mark A., Pagano, Patrick J., DeVallance, Evan R., Miles, George, Potoka, Karin P., Isenberg, Jeffrey S., Gladwin, Mark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620668/
https://ncbi.nlm.nih.gov/pubmed/30892078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00302.2018
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