TSP1–CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction

AIMS: Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1(−/−) mice are protected from pulmonary hypertension (PH). We hypothesized the TSP1–CD47 axis is upregulated in human PH and promotes pulmonary arterial vasculopathy. METHODS AND RESULTS: We analyzed the molecular signature and functional re...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Rogers, Natasha M., Sharifi-Sanjani, Maryam, Yao, Mingyi, Ghimire, Kedar, Bienes-Martinez, Raquel, Mutchler, Stephanie M., Knupp, Heather E., Baust, Jeffrey, Novelli, Enrico M., Ross, Mark, St. Croix, Claudette, Kutten, Johannes C., Czajka, Caitlin A., Sembrat, John C., Rojas, Mauricio, Labrousse-Arias, David, Bachman, Timothy N., Vanderpool, Rebecca R., Zuckerbraun, Brian S., Champion, Hunter C., Mora, Ana L., Straub, Adam C., Bilonick, Richard A., Calzada, Maria J., Isenberg, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220673/
https://ncbi.nlm.nih.gov/pubmed/27742621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw218
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