Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis

The mammalian target of rapamycin (mTOR) regulates cell growth in response to various intracellular and extracellular signals. It assembles into two multiprotein complexes: the rapamycin-sensitive mTOR complex 1 (mTORC1) and the rapamycin-insensitive mTORC2. In this study, we inactivated mTORC1 in m...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Cloëtta, Dimitri, Thomanetz, Venus, Baranek, Constanze, Lustenberger, Regula M., Lin, Shuo, Oliveri, Filippo, Atanasoski, Suzana, Rüegg, Markus A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618947/
https://ncbi.nlm.nih.gov/pubmed/23637172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3294-12.2013
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