Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

Mammalian target of rapamycin complex 1 (mTORC1) is central to the control of cell, organ, and body size. Skeletal muscle-specific inactivation of mTORC1 in mice results in smaller muscle fibers, fewer mitochondria, increased glycogen stores, and a progressive myopathy that causes premature death. I...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Romanino, Klaas, Mazelin, Laetitia, Albert, Verena, Conjard-Duplany, Agnès, Lin, Shuo, Bentzinger, C. Florian, Handschin, Christoph, Puigserver, Pere, Zorzato, Francesco, Schaeffer, Laurent, Gangloff, Yann-Gaël, Rüegg, Markus A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251091/
https://ncbi.nlm.nih.gov/pubmed/22143799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111448109
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados