Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

Mammalian target of rapamycin complex 1 (mTORC1) is central to the control of cell, organ, and body size. Skeletal muscle-specific inactivation of mTORC1 in mice results in smaller muscle fibers, fewer mitochondria, increased glycogen stores, and a progressive myopathy that causes premature death. I...

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Autors principals: Romanino, Klaas, Mazelin, Laetitia, Albert, Verena, Conjard-Duplany, Agnès, Lin, Shuo, Bentzinger, C. Florian, Handschin, Christoph, Puigserver, Pere, Zorzato, Francesco, Schaeffer, Laurent, Gangloff, Yann-Gaël, Rüegg, Markus A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251091/
https://ncbi.nlm.nih.gov/pubmed/22143799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111448109
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