Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

BACKGROUND: The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial effects on various muscle disorders and age‐related patholog...

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Bibliografski detalji
Izdano u:J Cachexia Sarcopenia Muscle
Glavni autori: Zhang, Qing, Duplany, Agnès, Moncollin, Vincent, Mouradian, Sandrine, Goillot, Evelyne, Mazelin, Laetitia, Gauthier, Karine, Streichenberger, Nathalie, Angleraux, Céline, Chen, Jie, Ding, Shuzhe, Schaeffer, Laurent, Gangloff, Yann‐Gaël
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438346/
https://ncbi.nlm.nih.gov/pubmed/30461220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12336
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