Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

BACKGROUND: The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial effects on various muscle disorders and age‐related patholog...

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Bibliografiske detaljer
Udgivet i:J Cachexia Sarcopenia Muscle
Main Authors: Zhang, Qing, Duplany, Agnès, Moncollin, Vincent, Mouradian, Sandrine, Goillot, Evelyne, Mazelin, Laetitia, Gauthier, Karine, Streichenberger, Nathalie, Angleraux, Céline, Chen, Jie, Ding, Shuzhe, Schaeffer, Laurent, Gangloff, Yann‐Gaël
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438346/
https://ncbi.nlm.nih.gov/pubmed/30461220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12336
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