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The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling pathway, leading to increased synaptic proteins in the prefrontal cortex (PFC) of rats. Our postmortem studies indicate robust deficits in promine...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3154612/ https://ncbi.nlm.nih.gov/pubmed/21635931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pnpbp.2011.05.010 |
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