The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling pathway, leading to increased synaptic proteins in the prefrontal cortex (PFC) of rats. Our postmortem studies indicate robust deficits in promine...

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Main Authors: Jernigan, Courtney S., Goswami, Dharmendra B., Austin, Mark C., Iyo, Abiye H., Chandran, Agata, Stockmeier, Craig A., Karolewicz, Beata
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154612/
https://ncbi.nlm.nih.gov/pubmed/21635931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pnpbp.2011.05.010
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