mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

The mammalian target of rapamycin (mTOR) signaling pathway in pulmonary fibrosis was investigated in cell and animal models. mTOR overactivation in alveolar epithelial cells (AECs) was achieved in the conditional and inducible Tsc1 knock-down mice SPC-rtTA/TetO-Cre/Tsc1 (fx/+) (STT). Doxycycline cau...

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Veröffentlicht in:PLoS One
Hauptverfasser: Gui, Yao-Song, Wang, Lianmei, Tian, Xinlun, Li, Xue, Ma, Aiping, Zhou, Weixun, Zeng, Ni, Zhang, Ji, Cai, Baiqiang, Zhang, Hongbing, Chen, Jing-Yu, Xu, Kai-Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575195/
https://ncbi.nlm.nih.gov/pubmed/26382847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138625
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