mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

The mammalian target of rapamycin (mTOR) signaling pathway in pulmonary fibrosis was investigated in cell and animal models. mTOR overactivation in alveolar epithelial cells (AECs) was achieved in the conditional and inducible Tsc1 knock-down mice SPC-rtTA/TetO-Cre/Tsc1 (fx/+) (STT). Doxycycline cau...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gui, Yao-Song, Wang, Lianmei, Tian, Xinlun, Li, Xue, Ma, Aiping, Zhou, Weixun, Zeng, Ni, Zhang, Ji, Cai, Baiqiang, Zhang, Hongbing, Chen, Jing-Yu, Xu, Kai-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575195/
https://ncbi.nlm.nih.gov/pubmed/26382847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138625
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