mTOR Overactivation in Mesenchymal cells Aggravates CCl(4)− Induced liver Fibrosis

Hepatic stellate cells are of mesenchymal cell type located in the space of Disse. Upon liver injury, HSCs transactivate into myofibroblasts with increase in expression of fibrillar collagen, especially collagen I and III, leading to liver fibrosis. Previous studies have shown mTOR signaling is acti...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shan, Lanlan, Ding, Yan, Fu, You, Zhou, Ling, Dong, Xiaoying, Chen, Shunzhi, Wu, Hongyuan, Nai, Wenqing, Zheng, Hang, Xu, Wanfu, Bai, Xiaochun, Jia, Chunhong, Dai, Meng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098141/
https://ncbi.nlm.nih.gov/pubmed/27819329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36037
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