Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

BACKGROUND: The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial effects on various muscle disorders and age‐related patholog...

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Detaylı Bibliyografya
Yayımlandı:J Cachexia Sarcopenia Muscle
Asıl Yazarlar: Zhang, Qing, Duplany, Agnès, Moncollin, Vincent, Mouradian, Sandrine, Goillot, Evelyne, Mazelin, Laetitia, Gauthier, Karine, Streichenberger, Nathalie, Angleraux, Céline, Chen, Jie, Ding, Shuzhe, Schaeffer, Laurent, Gangloff, Yann‐Gaël
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438346/
https://ncbi.nlm.nih.gov/pubmed/30461220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12336
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