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The Impact of Pathogenic Mitochondrial DNA Mutations on Substantia Nigra Neurons

Mitochondrial defects within substantia nigra (SN) neurons are implicated in the pathogenesis of Parkinson's disease. SN neurons show increased mitochondrial defects, mitochondrial DNA deletion levels, and susceptibility to such dysfunction, although the role of mitochondria in neuronal degener...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Reeve, Amy, Meagher, Martin, Lax, Nichola, Simcox, Eve, Hepplewhite, Philippa, Jaros, Evelyn, Turnbull, Doug
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618501/
https://ncbi.nlm.nih.gov/pubmed/23804100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3525-12.2013
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