The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons

Clonally expanded mitochondrial DNA (mtDNA) deletions accumulate with age in human substantia nigra (SN) and high levels cause respiratory chain deficiency. In other human tissues, mtDNA point mutations clonally expand with age. Here, the abundance of mtDNA point mutations within single SN neurons f...

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Detalhes bibliográficos
Main Authors: Reeve, Amy K, Krishnan, Kim J, Taylor, Geoffrey, Elson, Joanna L, Bender, Andreas, Taylor, Robert W, Morris, Christopher M, Turnbull, Doug M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Short Takes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759982/
https://ncbi.nlm.nih.gov/pubmed/19489744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2009.00492.x
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