The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons

Clonally expanded mitochondrial DNA (mtDNA) deletions accumulate with age in human substantia nigra (SN) and high levels cause respiratory chain deficiency. In other human tissues, mtDNA point mutations clonally expand with age. Here, the abundance of mtDNA point mutations within single SN neurons f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Reeve, Amy K, Krishnan, Kim J, Taylor, Geoffrey, Elson, Joanna L, Bender, Andreas, Taylor, Robert W, Morris, Christopher M, Turnbull, Doug M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Publishing Ltd 2009
Pynciau:
Short Takes
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759982/
https://ncbi.nlm.nih.gov/pubmed/19489744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2009.00492.x
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