The Impact of Pathogenic Mitochondrial DNA Mutations on Substantia Nigra Neurons

Mitochondrial defects within substantia nigra (SN) neurons are implicated in the pathogenesis of Parkinson's disease. SN neurons show increased mitochondrial defects, mitochondrial DNA deletion levels, and susceptibility to such dysfunction, although the role of mitochondria in neuronal degener...

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Publicado en:J Neurosci
Autores principales: Reeve, Amy, Meagher, Martin, Lax, Nichola, Simcox, Eve, Hepplewhite, Philippa, Jaros, Evelyn, Turnbull, Doug
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618501/
https://ncbi.nlm.nih.gov/pubmed/23804100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3525-12.2013
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