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Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson’s disease

Mitochondrial dysfunction within the cell bodies of substantia nigra neurons is prominent in both ageing and Parkinson’s disease. The loss of dopaminergic substantia nigra neurons in Parkinson’s disease is associated with loss of synapses within the striatum, and this may precede neuronal loss. We i...

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Bibliografiske detaljer
Udgivet i:NPJ Parkinsons Dis
Main Authors: Reeve, Amy K., Grady, John P., Cosgrave, Eve M., Bennison, Emma, Chen, Chun, Hepplewhite, Philippa D., Morris, Christopher M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979968/
https://ncbi.nlm.nih.gov/pubmed/29872690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-018-0044-6
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