The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons

Clonally expanded mitochondrial DNA (mtDNA) deletions accumulate with age in human substantia nigra (SN) and high levels cause respiratory chain deficiency. In other human tissues, mtDNA point mutations clonally expand with age. Here, the abundance of mtDNA point mutations within single SN neurons f...

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Hauptverfasser: Reeve, Amy K, Krishnan, Kim J, Taylor, Geoffrey, Elson, Joanna L, Bender, Andreas, Taylor, Robert W, Morris, Christopher M, Turnbull, Doug M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2009
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759982/
https://ncbi.nlm.nih.gov/pubmed/19489744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2009.00492.x
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