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Why Are Some Enzymes Dimers? Flexibility and Catalysis in Thermotoga maritima Dihydrofolate Reductase

[Image: see text] Dihydrofolate reductase from Thermotoga maritima (TmDFHFR) is a dimeric thermophilic enzyme that catalyzes the hydride transfer from the cofactor NADPH to dihydrofolate less efficiently than other DHFR enzymes, such as the mesophilic analogue Escherichia coli DHFR (EcDHFR). Using Q...

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Détails bibliographiques
Publié dans:ACS Catal
Auteurs principaux: Ruiz-Pernía, J. Javier, Tuñón, Iñaki, Moliner, Vicent, Allemann, Rudolf K.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614790/
https://ncbi.nlm.nih.gov/pubmed/31289693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b01250
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