Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

Protein dynamics have controversially been proposed to be at the heart of enzyme catalysis, but identification and analysis of dynamical effects in enzyme-catalyzed reactions have proved very challenging. Here, we tackle this question by comparing an enzyme with its heavy ((15)N, (13)C, (2)H substit...

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Main Authors: Luk, Louis Y. P., Javier Ruiz-Pernía, J., Dawson, William M., Roca, Maite, Loveridge, E. Joel, Glowacki, David R., Harvey, Jeremy N., Mulholland, Adrian J., Tuñón, Iñaki, Moliner, Vicent, Allemann, Rudolf K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799346/
https://ncbi.nlm.nih.gov/pubmed/24065822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312437110
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