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Unraveling the role of protein dynamics in dihydrofolate reductase catalysis
Protein dynamics have controversially been proposed to be at the heart of enzyme catalysis, but identification and analysis of dynamical effects in enzyme-catalyzed reactions have proved very challenging. Here, we tackle this question by comparing an enzyme with its heavy ((15)N, (13)C, (2)H substit...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799346/ https://ncbi.nlm.nih.gov/pubmed/24065822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312437110 |
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