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Minimization of dynamic effects in the evolution of dihydrofolate reductase
Protein isotope labeling is a powerful technique to probe functionally important motions in enzyme catalysis and can be applied to investigate the conformational dynamics of proteins. Previous investigations have indicated that dynamic coupling is detrimental to catalysis by dihydrofolate reductase...
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| Veröffentlicht in: | Chem Sci |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6006479/ https://ncbi.nlm.nih.gov/pubmed/29997817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04209g |
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