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Loss of Hyperconjugative Effects Drives Hydride Transfer during Dihydrofolate Reductase Catalysis
[Image: see text] Hydride transfer is widespread in nature and has an essential role in applied research. However, the mechanisms of how this transformation occurs in living organisms remain a matter of vigorous debate. Here, we examined dihydrofolate reductase (DHFR), an enzyme that catalyzes hydri...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Catal |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical Society
2019
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| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7007191/ https://ncbi.nlm.nih.gov/pubmed/32051770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b02839 |
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