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Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima.
DHFR (dihydrofolate reductase) catalyses the metabolically important reduction of 7,8-dihydrofolate by NADPH. DHFR from the hyperthermophilic bacterium Thermotoga maritima (TmDHFR), which shares similarity with DHFR from Escherichia coli, has previously been characterized structurally. Its tertiary...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223599/ https://ncbi.nlm.nih.gov/pubmed/12765545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030412 |
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