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Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis
The catalytic cycle of an enzyme is frequently associated with conformational changes that may limit maximum catalytic throughput. In Escherichia coli dihydrofolate reductase, release of tetrahydrofolate (THF) product is the rate-determining step under physiological conditions and is associated with...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562322/ https://ncbi.nlm.nih.gov/pubmed/18690714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801102e |
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