Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima.

DHFR (dihydrofolate reductase) catalyses the metabolically important reduction of 7,8-dihydrofolate by NADPH. DHFR from the hyperthermophilic bacterium Thermotoga maritima (TmDHFR), which shares similarity with DHFR from Escherichia coli, has previously been characterized structurally. Its tertiary...

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Bibliographische Detailangaben
Hauptverfasser: Maglia, Giovanni, Javed, Masood H, Allemann, Rudolf K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223599/
https://ncbi.nlm.nih.gov/pubmed/12765545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030412
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