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Minimization of dynamic effects in the evolution of dihydrofolate reductase

Protein isotope labeling is a powerful technique to probe functionally important motions in enzyme catalysis and can be applied to investigate the conformational dynamics of proteins. Previous investigations have indicated that dynamic coupling is detrimental to catalysis by dihydrofolate reductase...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Chem Sci
Päätekijät: Ruiz-Pernía, J. Javier, Behiry, Enas, Luk, Louis Y. P., Loveridge, E. Joel, Tuñón, Iñaki, Moliner, Vicent, Allemann, Rudolf K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Royal Society of Chemistry 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006479/
https://ncbi.nlm.nih.gov/pubmed/29997817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04209g
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