Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

Cancer cells with heterogeneous mutation landscapes and extensive functional redundancy easily develop resistance to monotherapies by emerging activation of compensating or bypassing pathways. To achieve more effective and sustained clinical responses, synergistic interactions of multiple druggable...

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Vydáno v:NPJ Syst Biol Appl
Hlavní autoři: Tang, Jing, Gautam, Prson, Gupta, Abhishekh, He, Liye, Timonen, Sanna, Akimov, Yevhen, Wang, Wenyu, Szwajda, Agnieszka, Jaiswal, Alok, Turei, Denes, Yadav, Bhagwan, Kankainen, Matti, Saarela, Jani, Saez-Rodriguez, Julio, Wennerberg, Krister, Aittokallio, Tero
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614366/
https://ncbi.nlm.nih.gov/pubmed/31312514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-019-0098-z
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