Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

Cancer cells with heterogeneous mutation landscapes and extensive functional redundancy easily develop resistance to monotherapies by emerging activation of compensating or bypassing pathways. To achieve more effective and sustained clinical responses, synergistic interactions of multiple druggable...

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Detalhes bibliográficos
Publicado no:NPJ Syst Biol Appl
Main Authors: Tang, Jing, Gautam, Prson, Gupta, Abhishekh, He, Liye, Timonen, Sanna, Akimov, Yevhen, Wang, Wenyu, Szwajda, Agnieszka, Jaiswal, Alok, Turei, Denes, Yadav, Bhagwan, Kankainen, Matti, Saarela, Jani, Saez-Rodriguez, Julio, Wennerberg, Krister, Aittokallio, Tero
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614366/
https://ncbi.nlm.nih.gov/pubmed/31312514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-019-0098-z
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