VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway

Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and spinal muscular atrophy. Previous studies have argued that ER stress may underlie the demise of neurons. We find that loss of VAP proteins (VAPs) leads to an accumulation of aberrant lysosomes and impairs lysoso...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Mao, Dongxue, Lin, Guang, Tepe, Burak, Zuo, Zhongyuan, Tan, Kai Li, Senturk, Mumine, Zhang, Sheng, Arenkiel, Benjamin R, Sardiello, Marco, Bellen, Hugo J.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613884/
https://ncbi.nlm.nih.gov/pubmed/30741620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1580103
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados