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Ubiquilins Regulate Autophagic Flux through mTOR Signaling and Lysosomal Acidification

Although the etiology of ALS remains poorly understood, impaired proteostasis is a common feature of different forms of ALS. Mutations in Ubiquilins, UBQLN2 and UBQLN4, cause familial ALS. The role of UBQLNs in proteasomal degradation is well established but their role in autophagy-lysosomal clearan...

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書誌詳細
出版年:Nat Cell Biol
主要な著者: Şentürk, Mümine, Lin, Guang, Zuo, Zhongyuan, Mao, Dongxue, Watson, Emma, Mikos, Antonios G., Bellen, Hugo J.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534127/
https://ncbi.nlm.nih.gov/pubmed/30804504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0281-x
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