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Ubiquilins Regulate Autophagic Flux through mTOR Signaling and Lysosomal Acidification
Although the etiology of ALS remains poorly understood, impaired proteostasis is a common feature of different forms of ALS. Mutations in Ubiquilins, UBQLN2 and UBQLN4, cause familial ALS. The role of UBQLNs in proteasomal degradation is well established but their role in autophagy-lysosomal clearan...
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| Publicado no: | Nat Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6534127/ https://ncbi.nlm.nih.gov/pubmed/30804504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0281-x |
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