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Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes

Abnormal accumulation of proteins is a hallmark of a variety of neurological diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Maintenance of protein homeostasis (proteostasis) in neurons via proteasomal and macroautophagy/autophagy-lysosomal degradation is th...

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Pubblicato in:Autophagy
Autori principali: Şentürk, Mümine, Mao, Dongxue, Bellen, Hugo J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613899/
https://ncbi.nlm.nih.gov/pubmed/31032688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1609863
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