VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway

Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and spinal muscular atrophy. Previous studies have argued that ER stress may underlie the demise of neurons. We find that loss of VAP proteins (VAPs) leads to an accumulation of aberrant lysosomes and impairs lysoso...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Mao, Dongxue, Lin, Guang, Tepe, Burak, Zuo, Zhongyuan, Tan, Kai Li, Senturk, Mumine, Zhang, Sheng, Arenkiel, Benjamin R, Sardiello, Marco, Bellen, Hugo J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613884/
https://ncbi.nlm.nih.gov/pubmed/30741620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1580103
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