Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification

BACKGROUND: The clinical use of doxorubicin is limited by cardiotoxicity. Histopathologic changes include interstitial myocardial fibrosis and appearance of vacuolated cardiomyocytes. Whereas dysregulation of autophagy in the myocardium has been implicated in a variety of cardiovascular diseases, th...

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Udgivet i:Circulation
Main Authors: Li, Dan L., Wang, Zhao V., Ding, Guanqiao, Tan, Wei, Luo, Xiang, Criollo, Alfredo, Xie, Min, Jiang, Nan, May, Herman, Kyrychenko, Viktoriia, Schneider, Jay W., Gillette, Thomas G., Hill, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856587/
https://ncbi.nlm.nih.gov/pubmed/26984939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.017443
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