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SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics
Despite the crucial role of RAF kinases in cell signaling and disease, we still lack a complete understanding of their regulation. Heterodimerization of RAF kinases as well as dephosphorylation of a conserved “S259” inhibitory site are important steps for RAF activation but the precise mechanisms an...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6613145/ https://ncbi.nlm.nih.gov/pubmed/31213532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902658116 |
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