SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by dephosphorylating a critical inhibitory site on R...

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Udgivet i:Nat Commun
Main Authors: Jones, Greg G., del Río, Isabel Boned, Sari, Sibel, Sekerim, Aysen, Young, Lucy C., Hartig, Nicole, Areso Zubiaur, Itziar, El-Bahrawy, Mona A., Hynds, Rob E., Lei, Winnie, Molina-Arcas, Miriam, Downward, Julian, Rodriguez-Viciana, Pablo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557854/
https://ncbi.nlm.nih.gov/pubmed/31182717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10367-x
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