The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

Shoc2/SUR-8 positively regulates Ras/ERK MAP kinase signaling by serving as a scaffold for Ras and Raf. Here, we examined the role of Shoc2 in the spatio-temporal regulation of Ras by using a fluorescence resonance energy transfer (FRET)-based biosensor, together with computational modeling. In epid...

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Detalhes bibliográficos
Main Authors: Matsunaga-Udagawa, Rie, Fujita, Yoshihisa, Yoshiki, Sayaka, Terai, Kenta, Kamioka, Yuji, Kiyokawa, Etsuko, Yugi, Katsuyuki, Aoki, Kazuhiro, Matsuda, Michiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844225/
https://ncbi.nlm.nih.gov/pubmed/20051520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053975
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