SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics

Despite the crucial role of RAF kinases in cell signaling and disease, we still lack a complete understanding of their regulation. Heterodimerization of RAF kinases as well as dephosphorylation of a conserved “S259” inhibitory site are important steps for RAF activation but the precise mechanisms an...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Boned del Río, Isabel, Young, Lucy C., Sari, Sibel, Jones, Greg G., Ringham-Terry, Benjamin, Hartig, Nicole, Rejnowicz, Ewa, Lei, Winnie, Bhamra, Amandeep, Surinova, Silvia, Rodriguez-Viciana, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613145/
https://ncbi.nlm.nih.gov/pubmed/31213532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902658116
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