SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis

Dephosphorylation of the inhibitory “S259” site on RAF kinases (S259 on CRAF, S365 on BRAF) plays a key role in RAF activation. The MRAS GTPase, a close relative of RAS oncoproteins, interacts with SHOC2 and protein phosphatase 1 (PP1) to form a heterotrimeric holoenzyme that dephosphorylates this S...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Young, Lucy C., Hartig, Nicole, Boned del Río, Isabel, Sari, Sibel, Ringham-Terry, Benjamin, Wainwright, Joshua R., Jones, Greg G., McCormick, Frank, Rodriguez-Viciana, Pablo
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
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PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233131/
https://ncbi.nlm.nih.gov/pubmed/30348783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720352115
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