In Vivo Metabolism of Ibuprofen in Growing Conventional Pigs: A Pharmacokinetic Approach

The juvenile conventional pig has been suggested as a preclinical animal model to evaluate pharmacokinetic (PK), pharmacodynamic (PD), and safety parameters in children. However, a lot of developmental changes in pig physiology still need to be unraveled. While the in vitro ontogeny of pig biotransf...

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Vydáno v:Front Pharmacol
Hlavní autoři: Millecam, Joske, De Baere, Siegrid, Croubels, Siska, Devreese, Mathias
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610244/
https://ncbi.nlm.nih.gov/pubmed/31316382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00712
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