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The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research

Since the implementation of several legislations to improve pediatric drug research, more pediatric clinical trials are being performed. In order to optimize these pediatric trials, adequate preclinical data are necessary, which are usually obtained by juvenile animal models. The growing piglet has...

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Publicado en:Front Pharmacol
Autores principales: Millecam, Joske, De Clerck, Laura, Govaert, Elisabeth, Devreese, Mathias, Gasthuys, Elke, Schelstraete, Wim, Deforce, Dieter, De Bock, Lies, Van Bocxlaer, Jan, Sys, Stanislas, Croubels, Siska
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960725/
https://ncbi.nlm.nih.gov/pubmed/29867477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00470
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