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Impact of Subacute Exposure to T-2 Toxin and Zearalenone on the Pharmacokinetics of Midazolam as CYP3A Probe Drug in a Porcine Animal Model: A Pilot Study

Cytochrome P450 enzymes (CYP) are important catalyzing proteins involved in the biotransformation of endogenous and xenobiotic compounds. However, their expression and/or activity can be altered by exposure to contaminants such as mycotoxins. In vitro incubations in porcine hepatic microsomes reveal...

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Publicado en:Front Pharmacol
Autores principales: Schelstraete, Wim, Devreese, Mathias, Croubels, Siska
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492070/
https://ncbi.nlm.nih.gov/pubmed/31105561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00399
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