Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective

Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism. Porcine CYP450 has been demonstrated to convert typical substrates of human CYP450. Ne...

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Vydáno v:Sci Rep
Hlavní autoři: Schelstraete, Wim, Clerck, Laura De, Govaert, Elisabeth, Millecam, Joske, Devreese, Mathias, Deforce, Dieter, Bocxlaer, Jan Van, Croubels, Siska
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592956/
https://ncbi.nlm.nih.gov/pubmed/31239454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45212-0
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