Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling

The Göttingen Minipig is gaining ground as nonrodent species in safety testing of drugs for pediatric indications. Due to developmental changes in pharmacokinetics and pharmacodynamics, physiologically based pharmacokinetic (PBPK) models are built to better predict drug exposure in children and to a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Pharmacol
Egile Nagusiak: Buyssens, Laura, De Clerck, Laura, Schelstraete, Wim, Dhaenens, Maarten, Deforce, Dieter, Ayuso, Miriam, Van Ginneken, Chris, Van Cruchten, Steven
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2021
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082684/
https://ncbi.nlm.nih.gov/pubmed/33935788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.665644
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