Postnatal Maturation of the Glomerular Filtration Rate in Conventional Growing Piglets As Potential Juvenile Animal Model for Preclinical Pharmaceutical Research

Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation. Over the years, pigs were presented as a potential animal model, since they display a high degree of anatomical and physiological similarities...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Gasthuys, Elke, Devreese, Mathias, Millecam, Joske, Sys, Stanislas, Vanderperren, Katrien, Delanghe, Joris, Vande Walle, Johan, Heyndrickx, Marjolein, Croubels, Siska
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489626/
https://ncbi.nlm.nih.gov/pubmed/28706488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00431
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