Postnatal Maturation of the Glomerular Filtration Rate in Conventional Growing Piglets As Potential Juvenile Animal Model for Preclinical Pharmaceutical Research

Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation. Over the years, pigs were presented as a potential animal model, since they display a high degree of anatomical and physiological similarities...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Gasthuys, Elke, Devreese, Mathias, Millecam, Joske, Sys, Stanislas, Vanderperren, Katrien, Delanghe, Joris, Vande Walle, Johan, Heyndrickx, Marjolein, Croubels, Siska
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489626/
https://ncbi.nlm.nih.gov/pubmed/28706488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00431
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