Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's disease (AD). Studies in animal models of tauopathy suggest that tau oligomers play a key role in eliciting...

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Pubblicato in:J Neurosci
Autori principali: Castillo-Carranza, Diana L., Sengupta, Urmi, Guerrero-Muñoz, Marcos J., Lasagna-Reeves, Cristian A., Gerson, Julia E., Singh, Gurpreet, Estes, D. Mark, Barrett, Alan D. T., Dineley, Kelly T., Jackson, George R., Kayed, Rakez
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2014
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608097/
https://ncbi.nlm.nih.gov/pubmed/24647946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3192-13.2014
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