Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's disease (AD). Studies in animal models of tauopathy suggest that tau oligomers play a key role in eliciting...

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Foilsithe in:J Neurosci
Main Authors: Castillo-Carranza, Diana L., Sengupta, Urmi, Guerrero-Muñoz, Marcos J., Lasagna-Reeves, Cristian A., Gerson, Julia E., Singh, Gurpreet, Estes, D. Mark, Barrett, Alan D. T., Dineley, Kelly T., Jackson, George R., Kayed, Rakez
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2014
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608097/
https://ncbi.nlm.nih.gov/pubmed/24647946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3192-13.2014
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