Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's disease (AD). Studies in animal models of tauopathy suggest that tau oligomers play a key role in eliciting...

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發表在:J Neurosci
Main Authors: Castillo-Carranza, Diana L., Sengupta, Urmi, Guerrero-Muñoz, Marcos J., Lasagna-Reeves, Cristian A., Gerson, Julia E., Singh, Gurpreet, Estes, D. Mark, Barrett, Alan D. T., Dineley, Kelly T., Jackson, George R., Kayed, Rakez
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2014
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608097/
https://ncbi.nlm.nih.gov/pubmed/24647946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3192-13.2014
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