Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

The Fanconi anemia proteins participate in a canonical pathway that repairs cross‐linking agent‐induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia‐deficient hematopoietic stem cells are also hypersensitive to inflammatory cyt...

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Dades bibliogràfiques
Publicat a:J Leukoc Biol
Autors principals: Garbati, Michael R., Hays, Laura E., Rathbun, R. Keaney, Jillette, Nathaniel, Chin, Kathy, Al‐Dhalimy, Muhsen, Agarwal, Anupriya, Newell, Amy E. Hanlon, Olson, Susan B., Bagby, Grover C.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Inflammation, Extracellular Mediators, & Effector Molecules
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608044/
https://ncbi.nlm.nih.gov/pubmed/26432900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0515-201R
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