Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

The Fanconi anemia proteins participate in a canonical pathway that repairs cross‐linking agent‐induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia‐deficient hematopoietic stem cells are also hypersensitive to inflammatory cyt...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Garbati, Michael R., Hays, Laura E., Rathbun, R. Keaney, Jillette, Nathaniel, Chin, Kathy, Al‐Dhalimy, Muhsen, Agarwal, Anupriya, Newell, Amy E. Hanlon, Olson, Susan B., Bagby, Grover C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Inflammation, Extracellular Mediators, & Effector Molecules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608044/
https://ncbi.nlm.nih.gov/pubmed/26432900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0515-201R
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