Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

The Fanconi anemia proteins participate in a canonical pathway that repairs cross‐linking agent‐induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia‐deficient hematopoietic stem cells are also hypersensitive to inflammatory cyt...

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Bibliografske podrobnosti
izdano v:J Leukoc Biol
Main Authors: Garbati, Michael R., Hays, Laura E., Rathbun, R. Keaney, Jillette, Nathaniel, Chin, Kathy, Al‐Dhalimy, Muhsen, Agarwal, Anupriya, Newell, Amy E. Hanlon, Olson, Susan B., Bagby, Grover C.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Inflammation, Extracellular Mediators, & Effector Molecules
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608044/
https://ncbi.nlm.nih.gov/pubmed/26432900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0515-201R
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