Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

The Fanconi anemia proteins participate in a canonical pathway that repairs cross‐linking agent‐induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia‐deficient hematopoietic stem cells are also hypersensitive to inflammatory cyt...

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Udgivet i:J Leukoc Biol
Main Authors: Garbati, Michael R., Hays, Laura E., Rathbun, R. Keaney, Jillette, Nathaniel, Chin, Kathy, Al‐Dhalimy, Muhsen, Agarwal, Anupriya, Newell, Amy E. Hanlon, Olson, Susan B., Bagby, Grover C.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Inflammation, Extracellular Mediators, & Effector Molecules
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608044/
https://ncbi.nlm.nih.gov/pubmed/26432900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0515-201R
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